Applied Cell Biology

Applied Cell Biology

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Regeneration Plate 3.0 – Improvement and Maintenance of Intestinal Health by Reduction of Oxidative Stress and Inflammation

Peter C. Dartsch*

Dartsch Scientific GmbH, Institute for Cell Biological Test Systems, Auf der Vosshardt 25, D-49419 Wagenfeld, Germany


Background: Sleep is an integral biological necessity and is understood to possess recuperative and regenerative properties. Sleep deprivation has been associated with diseases and an increase in morbidity and mortality. Several recent studies have suggested a strong relation between insufficient sleep and gastrointestinal diseases, especially when triggered by inflammatory processes. Accordingly to these findings it has been reported that sleep deprivation in both humans and experimental animals causes a progressive increase in circulating white blood cells, mainly neutrophils as well as an increase in various circulating proinflammatory molecules.

Experimental: Against this background we used cultured intestinal epithelial cells to investigate the positive impact of a specially designed device, Regeneration Plate 3.0, which is positioned under the bed during sleep and is stated to improve systemic health on the cellular level by reducing oxidative stress which acts on the body. The plate produces a vital field with a frequency pool containing all important regeneration frequencies within a radius of 90 cm. The body's own energy field only resonates with those frequencies that are required for an optimal supply of energy to the cells. The field strength of the vital field is adjusted in such a way that the energy system cannot be over-energized. In addition, we also used an in vitro model with inflammation-mediating cells (= functional neutrophils) to examine whether the Regeneration Plate 3.0 might be able to reduce the generation of reactive oxygen radicals during an inflammatory process.

Results: The results demonstrate that the Regeneration Plate 3.0 was able to reduce oxidative stress acting on intestinal epithelial cells. After 24 hours, the percentage of surviving cells after exposure to 2 mM hydrogen peroxide and the Regeneration Plate 3.0 for 8 hours was 27.7 ± 5.7%, while the viability of the untreated control cells was 14.7 ± 2.9% (mean values ± standard deviations). The difference between both experimental groups was statistically highly significant at the p ≤ 0.01 level. Moreover, the generation of superoxide anion radicals by functional neutrophils was reduced by nearly 50% in comparison to untreated control cells. Again, the difference between both groups was statistically highly significant at the p ≤ 0.01 level.

Conclusions: Both beneficial effects of the Regeneration Plate 3.0 shown in the present in vitro study can act on the body during sleep and might enhance not only intestinal health, but also systemic health and well-being.

Vital field; Regeneration Plate; Sleep; Intestinal health; Oxygen radicals; Oxidative stress; Intestinal cells; IPEC-J2; Functional neutrophils; HL-60; Oxidative burst; Inflammation; Cell culture
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