Effect of hyperglycemia and hypoxia on proliferation of normal and cancer cell lines
PaolaA.Valero,AlejandroA.Luzardo, Paula E.Durante
Laboratorio de Metabolismo Intermediario y Hormonas, Instituto Venezolano de Investigaciones Científicas, República Bolivar iana de Venezuela, (CHINA)
Recent reports indicate an increased incidence of cancer in type 2 diabetic patients. The mechanisms that promote the progression of cancer in such patients are not known but it is believed that hyperglycemia is the major cause. The objective of this study is to evaluate the effect of hyperglycemia and hypoxia in proliferating normal BHK21 and cancer H1299 cell lines. Cells were incubated for 18, 24 and 48 hours under normal, increased glucose concentrations (hyperglycemia) and decreased percentage of oxygen conditions (hypoxia).
Hyperglycemia; Hypoxia; Cancer; Proliferation; Metabolism.