Special Issue: Signaling Pathways in Osteoclast-driven Bone Metastases
Lead Editor: Dr. Tran Tien Manh
Call for papers
This Issue is now open for submissions.
Special issue information
Bone is a relatively common metastasis site of malignancy for the cancer cells preferentially derived from breast, prostate and even lungs. To date, there is no effective treatments for tumor-associated bone metastases, and this represents a real challenge for the world-wide researchers in cancer-related field. Osteoclasts, the myeloid lineage-derived boneresorbing cells of hematopoietic origin, differentiate from myeloid precursors through a complex regulation process. Gain-of-function in osteoclasts is frequently associated with bone metastases, enhancing bone resorption. Bone resorption results in the release of the minerals (in their ionic form), Ca2+ ions and growth factors into the extracellular matrix (ECM), synergistically promoting not only the osteoclast-induced bone resorption, but more importantly, survival, proliferation, differentiation and growth of metastatic cancer cells in bone.
This Special Issue on “Signaling Pathways in Osteoclast-driven Bone Metastases” intends to gather the cutting-edge research articles, review articles, mini-review, and communications in all fields of osteoclasts and osteoclast-caused bone metastases with a purpose of exploring and revealing the latest significant advances towards identifying unknown molecular mechanisms, and the specific features related to osteoclast-driven bone metastases”
Potential topics include but are not limited to the following:
Submissions of original research, review, case reports, commentary manuscripts, etc. are welcome from world-wide researchers in the field of bone metabolism in general, osteoclast-induced bone homeostasis in particular, and osteoclast-driven bone metastases to the special issue on “Signaling Pathways in osteoclast-driven bone metastases” for consideration for publication in our journal, Applied Cell Biology.
Dr. Tran Tien Manh
Okayama University, Japan
Articles on: Signaling Pathways in Osteoclast-driven Bone Metastases
Comparing Effectiveness of Different Microhomology Lengths in Microhomology Mediated End Joining (MMEJ) Repair of DNA Double Stranded Breaks (DSBs)
Vasanth Senthilraja, Rehet Chugh, Sehej Chugh2, Ethan Yang, Himanshu Wagh*
App Cell Biol | Open Access | 10.53043/2320-1991.acbS1005
Abstract | PDF | Full-Text