Applied Cell Biology

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Special Issue: Signaling Pathways in Osteoclast-driven Bone Metastases

Lead Editor: Dr. Tran Tien Manh

Call for papers

This Issue is now open for submissions.

Special issue information

Bone is a relatively common metastasis site of malignancy for the cancer cells preferentially derived from breast, prostate and even lungs. To date, there is no effective treatments for tumor-associated bone metastases, and this represents a real challenge for the world-wide researchers in cancer-related field. Osteoclasts, the myeloid lineage-derived boneresorbing cells of hematopoietic origin, differentiate from myeloid precursors through a complex regulation process. Gain-of-function in osteoclasts is frequently associated with bone metastases, enhancing bone resorption. Bone  resorption results in the release of the minerals (in their ionic form), Ca2+ ions and growth factors into the extracellular matrix (ECM), synergistically promoting not only the osteoclast-induced bone  resorption, but more importantly, survival, proliferation, differentiation and growth of metastatic  cancer cells in bone.

This Special Issue on “Signaling Pathways in Osteoclast-driven Bone Metastases” intends to gather the cutting-edge research articles, review articles, mini-review, and communications in all fields of osteoclasts and osteoclast-caused bone metastases with a purpose of exploring and revealing the latest significant advances towards identifying unknown molecular mechanisms, and the specific features related to osteoclast-driven bone metastases”


Potential topics include but are not limited to the following:

Submissions of original research, review, case reports, commentary manuscripts, etc. are welcome from world-wide researchers in the field of bone metabolism in general, osteoclast-induced bone homeostasis in particular, and osteoclast-driven bone metastases to the special issue on “Signaling Pathways in osteoclast-driven bone metastases” for consideration for publication in our journal, Applied Cell Biology.


Dr. Tran Tien Manh

Okayama University, Japan

Articles on: Signaling Pathways in Osteoclast-driven Bone Metastases

Signaling Pathways in Osteoclast-driven Bone Metastasis: A mini-review

Manh Tien Tran

App Cell Biol | Open Access | 10.53043/2320-1991.acbS1004

PDF | Full-Text

Comparing Effectiveness of Different Microhomology Lengths in Microhomology Mediated End Joining (MMEJ) Repair of DNA Double Stranded Breaks (DSBs)

Vasanth Senthilraja, Rehet Chugh, Sehej Chugh, Ethan Yang, Himanshu Wagh*

App Cell Biol | Open Access | 10.53043/2320-1991.acbS1005

Abstract | PDF | Full-Text

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