Method to Improve Administered Cells Via Intramuscular Route to Augment Efficacy of Regenerative Cell Therapy in The Field of Peripheral Artery Disease
Keisuke Miyake, Shigeru Miyagawa, Yoshiki Sawa*
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan
In the field of peripheral artery disease (PAD), regenerative cell therapy has been expected to be a new alternative therapy especially for severely diseased patients. Although various preclinical studies showed promising results, those therapies failed to show sufficient efficacy for actual PAD patients and current guideline do not recommend regenerative therapy for PAD. The disappointing result may be caused by low retention rate of administered substance. Recently we published an article regarding novel method to augment the effect of cell therapy. In this review article, we would like to focus on the importance of improvement in cell survival and prerequisite factors to develop effective regenerative therapy for PAD patients.