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Autoantibodies in Females Exposed to Indoor Air Dampness Microbiota and Complaining of Electromagnetic Hypersensitivity-The Case Control Report

Tamara Tuuminen1*, Itai Katz2,3, Kirsi Vaali4, Harald Heidecke5, Gilad Halpert2,3, Howard Amital2,3,6, Yehuda Shoenfeld7

1Kruunuhaka Medical Center, Kaisaniemenkatu 1Ba, 00 180 Helsinki, Finland
2Zabludowicz Center for Autoimmune Diseases, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
3Sheba Medical Center, Tel-Hashomer, Ramat- Gan, 52621, Israel
4SelexLab, Kalevankatu 20, Helsinki 00100, Finland
5CellTrend GmbH Im Biotechnologiepark 3 D-14943 Luckenwalde, Germany
6Department of Medicine ‘B’ and Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Israel
7Ariel University, Ariel, Israel


We hypothesized that prolonged or cumulative exposure to indoor air dampness microbiota in moisture-damaged buildings and daily exposure to wireless telecommunication devices would potentiate the risk of electromagnetic
hypersensitivity (EHS), which is poorly defined.
We performed a nested comparative analysis within an age- and sex-matched study of females who were exposed to dampness microbiota with self-reported complaints compatible with EHS (n=11). Their levels of autoantibodies towards 13 different
autoantigens were measured.
EHS presented as multiple chemical sensitivity, profound fatigue, memory disturbances in all subjects (11/11), and cognitive impairment in the majority (9/11). When comparing the patients to controls, no difference was detected between the
levels of the following autoantibodies: angiotensin II type 1 receptor (AGTR1), endothelin receptor type A (ETAR), adrenergic receptors α1AR, α2AR, β1AR, β2AR and cholinergic muscarinic receptors m1AChR, m2AChR, m3AChR and m5AChR.
In contrast, IgG levels towards m4AChR and fibroblast growth factor receptor 3 (FGFR3), and IgM autoantibodies against glycosylated moieties of heparan and heparan sulphate (TS-HDS) were significantly decreased in the study cohort,
p=0.008; p=0.032, p<0.001, respectively.
This is the first report demonstrating an imbalance in the nervous system autoantibodies in patients with EHS. The clinical significance of these altered responses remains to be clarified.

autonomous nervous system; dampness and mold hypersensitivity syndrome (DMHS); sick building syndrome, autoantibodies, neurological symptoms, electromagnetic hypersensitivity.
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