Special Issue: Signaling Pathways in Osteoclast-driven Bone Metastases
Lead Editor: Dr. Tran Tien Manh
Call for papers
This Issue is now open for submissions.
Special issue information
Bone is a relatively common metastasis site of malignancy for the cancer cells preferentially derived from breast, prostate and even lungs. To date, there is no effective treatments for tumor-associated bone metastases, and this represents a real challenge for the world-wide researchers in cancer-related field. Osteoclasts, the myeloid lineage-derived boneresorbing cells of hematopoietic origin, differentiate from myeloid precursors through a complex regulation process. Gain-of-function in osteoclasts is frequently associated with bone metastases, enhancing bone resorption. Bone resorption results in the release of the minerals (in their ionic form), Ca2+ ions and growth factors into the extracellular matrix (ECM), synergistically promoting not only the osteoclast-induced bone resorption, but more importantly, survival, proliferation, differentiation and growth of metastatic cancer cells in bone.
This Special Issue on “Signaling Pathways in Osteoclast-driven Bone Metastases” intends to gather the cutting-edge research articles, review articles, mini-review, and communications in all fields of osteoclasts and osteoclast-caused bone metastases with a purpose of exploring and revealing the latest significant advances towards identifying unknown molecular mechanisms, and the specific features related to osteoclast-driven bone metastases”
Potential topics include but are not limited to the following:
Submissions of original research, review, case reports, commentary manuscripts, etc. are welcome from world-wide researchers in the field of bone metabolism in general, osteoclast-induced bone homeostasis in particular, and osteoclast-driven bone metastases to the special issue on “Signaling Pathways in osteoclast-driven bone metastases” for consideration for publication in our journal, Applied Cell Biology.
Dr. Tran Tien Manh
Okayama University, Japan
Articles on: Signaling Pathways in Osteoclast-driven Bone Metastases