Applied Cell Biology

Matrix metalloproteinases and their tissue inhibitors in heart failure

Paul J.Lijnen, Yudi Purnomo, Yvette Piccart, Tamara Coenen, John S.Prihadi

¹Hypertension andCardiovascularRehabilitationUnit,DepartmentCardiovascular Sciences, CatholicUniversity ofLeuven(KULeuven),Leuven, (BELGIUM)
²University ofBrawijaya,Malang, (INDONESIA)

Abstract

The integrityof the extracellularmatrix ismaintained by a balanced interaction between the matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). In heart failure the levels ofMMPs and TIMPs are altered resulting in an imbalance.MMPs and TIMPs contribute to various aspects of cardiac remodeling and function. In the present review the contribution of MMPs and TIMPs to the development and progression of cardiac diseases will be discussed.

Keywords:

Metalloproteinases; Tissue inhibitors of metalloproteinases; Heart failure; Myocardial infarction; MMP inhibitors.