Applied Cell Biology

Applied Cell Biology

E-mail: editor@appliedcellbiology.com

Cytotoxic effect of Jamaican bissy nut extracts on various cancer cell lines

Henry I.C.Lowe, Charah T.Watson, Simone Badal, Patrice Peart, Ngeh J.Toyang, Joseph Bryant

1Bio-TechR&DInstitute,Kingston, (JAMAICA)
2Educational and ScientificCorporation, Florida, (USA)
3Institute ofHumanVirology,University ofMarylandSchool ofMedicine, Baltimore,MD, (USA)
4Natural Products Institute,University of theWest Indies,Mona, (JAMAICA)

Abstract

Given the high incidence of cancer worldwide and one of the main sources of unearthing novel lead molecules being medicinal plants, this research undertook to investigate the possible anti-cancer activity of five bissy plant extracts (hexane, dichloromethane, acetone, methanol and water) against three human cancer cell lines; prostate (PC-3 and DU-145), breast
cancer (BC) andmice melanoma (B16). Cytotoxicitywas measured using the trypan blue exclusion assay. The hexane extract was the most potent, particularly against, DU-145 and PC-3 cell lines, killing 95%of the cells at 160 μg/ml. These results will prove useful for further research and so may serve as leads for the development of new drugs.

Keywords:
Bissy; Cola acuminata; Prostate cancer; Breast cancer; Cytotoxic.
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